Michele Lomuto was born in Bari. He was skyrocketed to fame in 1982 by Luciano Berio as the foremost interpreter of his Sequenza V, and later as soloist in Ofanim, Albumblatt and Outis by the same composer. In 1989 Sylvano Busotti invited him to work on the music for the film Biennale Apollo and dedicated to him his piece Averla e Grifone for solo trombone (1987; most recent version: Los Angeles, 1991).
Michele Lomuto has made a tangible contribution to expanding the repertoire for solo trombone. Among the composers who have written pieces specially for him are Franco Donatoni (Scaglie), Luca Francesconi (Respiro), Azio Corghi (Intermedi e Canzoni), Giacomo Manzoni (Duplum), Aldo Clementi (Berceuse III for 12 wind instruments and obbligato trombone), as well as A. Gentilucci, G. Caslini, M. Panni, V. Mortari, M. Mengelberg, D. Wagenaar, A. Samori, G. Cardini, M. Bortolotti, F. De Rossi Re, F. Cifariello Ciardi, P. Piacentini, F. Scagliola and F. Degrassi.
Donatoni entrusted him with the first performance of his Sweet Basil for trombone and big band (Strasbourg, 1993).
Lomuto's honours include the Premio Internazionale Gino Tani (1993). Since 1997 he has taught at the Instituto di Filosofia e Scienze del Liguaggio of Bari University.